Progress and challenges in translating the biology of atherosclerosis-Libby et al Nature, 2011
Statins effectively lower LDL and CRP levels in humans. Analyses of several large studies of statins in primary- and secondary-prevention populations suggest that some of their clinical benefit accrues from an anti-inflammatory action distinct from LDL lowering. The hypothesis that an anti-inflammatory intervention can reduce cardiovascular events independent of lipoprotein effects still requires rigorous testing. Thus, despite hundreds of studies affirming a role for inflammation in atherosclerosis in mice, and many intriguing observations in humans...Koch’s postulates remain unfulfilled.
Any thoughts on this?